diff --git a/browser/app/nsBrowserApp.cpp b/browser/app/nsBrowserApp.cpp
index a85fdbfebe0f..819475717ffb 100644
--- a/browser/app/nsBrowserApp.cpp
+++ b/browser/app/nsBrowserApp.cpp
@@ -156,19 +156,30 @@ static bool IsArg(const char* arg, const char* s) {
 #endif
 
   return false;
 }
 
 MOZ_RUNINIT Bootstrap::UniquePtr gBootstrap;
 
 static int do_main(int argc, char* argv[], char* envp[]) {
+  // Allow profile downgrade for Zotero
+  _putenv_s("MOZ_ALLOW_DOWNGRADE", "1");
+  // Don't create dedicated profile (default-esr)
+  _putenv_s("MOZ_LEGACY_PROFILES", "1");
+
   // Allow firefox.exe to launch XULRunner apps via -app <application.ini>
   // Note that -app must be the *first* argument.
-  const char* appDataFile = getenv("XUL_APP_FILE");
+  UniqueFreePtr<char> iniPath = BinaryPath::GetApplicationIni();
+  if (!iniPath) {
+	  Output("Couldn't find application.ini.\n");
+	  return 255;
+
+  }
+  char *appDataFile = iniPath.get();
   if ((!appDataFile || !*appDataFile) && (argc > 1 && IsArg(argv[1], "app"))) {
     if (argc == 2) {
       Output("Incorrect number of arguments passed to -app");
       return 255;
     }
     appDataFile = argv[2];
 
     char appEnv[MAXPATHLEN];
diff --git a/browser/app/winlauncher/LauncherProcessWin.cpp b/browser/app/winlauncher/LauncherProcessWin.cpp
index 8167d2b81c91..a1ef657232bf 100644
--- a/browser/app/winlauncher/LauncherProcessWin.cpp
+++ b/browser/app/winlauncher/LauncherProcessWin.cpp
@@ -156,17 +156,31 @@ static mozilla::LauncherFlags ProcessCmdLine(int& aArgc, wchar_t* aArgv[]) {
                         mozilla::CheckArgFlag::None) == mozilla::ARG_FOUND ||
       mozilla::CheckArg(aArgc, aArgv, "remote-debugging-port", nullptr,
                         mozilla::CheckArgFlag::None) == mozilla::ARG_FOUND ||
       mozilla::EnvHasValue("MOZ_AUTOMATION") ||
       mozilla::EnvHasValue("MOZ_HEADLESS")) {
     result |= mozilla::LauncherFlags::eWaitForBrowser;
   }
 
-  if (mozilla::CheckArg(aArgc, aArgv, "no-deelevate") == mozilla::ARG_FOUND) {
+  // Disable deelevation for Zotero
+  //
+  // If people are running as Administrator, or in some cases running with
+  // UAC disabled, Word runs at integrity level High and deelevation drops
+  // Zotero down to Medium, which causes 'Could not find a running Word
+  // instance' errors.
+  //
+  // Even when not running as administrator, the process switch involved in
+  // deelevation also seems to be causing various security software, such as
+  // Cisco Secure Endpoint, to block Zotero from running:
+  // https://forums.zotero.org/discussion/116762
+  //
+  // Disabling deelevation returns us to the behavior of Zotero 6, Word, and
+  // most other programs
+  if (true || mozilla::CheckArg(aArgc, aArgv, "no-deelevate") == mozilla::ARG_FOUND) {
     result |= mozilla::LauncherFlags::eNoDeelevate;
   }
 
   if (mozilla::CheckArg(aArgc, aArgv, ATTEMPTING_DEELEVATION_FLAG) ==
       mozilla::ARG_FOUND) {
     result |= mozilla::LauncherFlags::eDeelevating;
   }
 
diff --git a/toolkit/mozapps/update/common/commonupdatedir.cpp b/toolkit/mozapps/update/common/commonupdatedir.cpp
index 0ba9fcef9417..ed286476fec3 100644
--- a/toolkit/mozapps/update/common/commonupdatedir.cpp
+++ b/toolkit/mozapps/update/common/commonupdatedir.cpp
@@ -38,17 +38,17 @@
 // (i.e. C:\ProgramData\<ROOT_UPDATE_DIR_NAME>)
 // It is really important that we properly set the permissions on this
 // directory at creation time. Thus, it is really important that this code be
 // the creator of this directory. We had many problems with the old update
 // directory having been previously created by old versions of Firefox. To avoid
 // this problem in the future, we are including a UUID in the root update
 // directory name to attempt to ensure that it will be created by this code and
 // won't already exist with the wrong permissions.
-#  define ROOT_UPDATE_DIR_NAME "Mozilla-1de4eec8-1241-4177-a864-e594e8d1fb38"
+#  define ROOT_UPDATE_DIR_NAME "Zotero"
 // This describes the directory between the "Mozilla" directory and the install
 // path hash (i.e. C:\ProgramData\Mozilla\<UPDATE_PATH_MID_DIR_NAME>\<hash>)
 #  define UPDATE_PATH_MID_DIR_NAME "updates"
 
 enum class WhichUpdateDir {
   CurrentUpdateDir,
   UnmigratedUpdateDir,
 };
diff --git a/xpcom/build/BinaryPath.h b/xpcom/build/BinaryPath.h
index 1718caa3c66d..10fa59c0cd80 100644
--- a/xpcom/build/BinaryPath.h
+++ b/xpcom/build/BinaryPath.h
@@ -283,16 +283,43 @@ class BinaryPath {
     if (NS_FAILED(Get(path))) {
       return nullptr;
     }
     UniqueFreePtr<char> result;
     result.reset(strdup(path));
     return result;
   }
 
+  static UniqueFreePtr<char> GetApplicationIni() {
+	char path[MAXPATHLEN];
+	if (NS_FAILED(Get(path))) {
+		return nullptr;
+	}
+
+	char *c = path + strlen(path);
+	while (c >= path && *c != '\\' && *c != '/') {
+		*c = NULL;
+		c--;
+	}
+
+	if (c < path) {
+		return nullptr;
+	}
+
+	char iniPath[MAXPATHLEN];
+	int n = snprintf(iniPath, MAXPATHLEN, "%s\\app\\application.ini", path);
+	if (n < 0 || n >= MAXPATHLEN) {
+		return nullptr;
+	}
+
+	UniqueFreePtr<char> result;
+	result.reset(strdup(iniPath));
+	return result;
+  }
+
 #ifdef MOZILLA_INTERNAL_API
   static nsresult GetFile(nsIFile** aResult) {
     nsCOMPtr<nsIFile> lf;
 #  ifdef XP_WIN
     wchar_t exePath[MAXPATHLEN];
     nsresult rv = GetW(exePath);
 #  else
     char exePath[MAXPATHLEN];