diff --git a/chrome/content/zotero/xpcom/prefs.js b/chrome/content/zotero/xpcom/prefs.js
index 3e9aaff3b4..4e9605f463 100644
--- a/chrome/content/zotero/xpcom/prefs.js
+++ b/chrome/content/zotero/xpcom/prefs.js
@@ -389,6 +389,23 @@ Zotero.Prefs = new function(){
 					try {
 						let path = OS.Path.fromFileURI(addon.getResourceURI().spec);
 						
+						// Hack to delete extensions.json for Mac users who first ran Zotero from the
+						// disk image and ended up with invalid integration plugin paths in
+						// extensions.json
+						try {
+							if (Zotero.isMac && path.includes('AppTranslocation')) {
+								await OS.File.remove(
+									OS.Path.join(Zotero.Profile.dir, 'extensions.json'),
+									{
+										ignoreAbsent: true
+									}
+								);
+							}
+						}
+						catch (e) {
+							Zotero.logError(e);
+						}
+						
 						// Directory
 						if ((await OS.File.stat(path)).isDir) {
 							let dir = OS.Path.join(path, 'defaults', 'preferences');
diff --git a/chrome/content/zotero/xpcom/zotero.js b/chrome/content/zotero/xpcom/zotero.js
index 83f2904e35..9e66e2a825 100644
--- a/chrome/content/zotero/xpcom/zotero.js
+++ b/chrome/content/zotero/xpcom/zotero.js
@@ -1816,6 +1816,21 @@ Services.scriptloader.loadSubScript("resource://zotero/polyfill.js");
 				Zotero.getString('general.quitApp', Zotero.clientName),
 				null, null, null, {}
 			);
+			
+			// If the integration plugins were installed from the AppTranslocation path, delete
+			// extensions.json
+			try {
+				let file = OS.Path.join(Zotero.Profile.dir, 'extensions.json');
+				let json = JSON.parse(Zotero.File.getContents(file));
+				if (json.addons.some(x => x.path.includes('AppTranslocation'))) {
+					file = Zotero.File.pathToFile(file);
+					file.remove(null);
+				}
+			}
+			catch (e) {
+				Zotero.logError(e);
+			}
+			
 			Zotero.Utilities.Internal.quit();
 			return false;
 		}