diff --git a/litellm/proxy/guardrails/guardrail_hooks/custom_code/sandbox.py b/litellm/proxy/guardrails/guardrail_hooks/custom_code/sandbox.py
index 35f1e6e6515..1588836f681 100644
--- a/litellm/proxy/guardrails/guardrail_hooks/custom_code/sandbox.py
+++ b/litellm/proxy/guardrails/guardrail_hooks/custom_code/sandbox.py
@@ -31,6 +31,7 @@ from RestrictedPython.Eval import default_guarded_getitem, default_guarded_getit
 from RestrictedPython.Guards import (
     full_write_guard,
     guarded_iter_unpack_sequence,
+    guarded_unpack_sequence,
     safer_getattr,
 )
 
@@ -115,6 +116,12 @@ def build_sandbox_globals() -> dict[str, object]:
         "_getitem_": default_guarded_getitem,
         "_getiter_": default_guarded_getiter,
         "_iter_unpack_sequence_": guarded_iter_unpack_sequence,
+        # RestrictedPython emits _unpack_sequence_ for every tuple-unpacking
+        # target that is not a for-loop target — ``a, b = pair``,
+        # ``a, *rest = seq``, ``with x as (a, b)`` — and, like _inplacevar_,
+        # ships no default. Without it those statements compile and then raise
+        # NameError the first time the guardrail runs.
+        "_unpack_sequence_": guarded_unpack_sequence,
         "_write_": full_write_guard,
         "_inplacevar_": _inplacevar_,
     }
diff --git a/tests/test_litellm/proxy/guardrails/test_custom_code_security.py b/tests/test_litellm/proxy/guardrails/test_custom_code_security.py
index 068cd0d8ed7..ac1b454b8b1 100644
--- a/tests/test_litellm/proxy/guardrails/test_custom_code_security.py
+++ b/tests/test_litellm/proxy/guardrails/test_custom_code_security.py
@@ -363,3 +363,32 @@ def test_augmented_assignment_works():
 def test_missing_apply_guardrail_raises():
     with pytest.raises(CustomCodeCompilationError, match="apply_guardrail"):
         _compile("x = 1\n")
+
+
+@pytest.mark.parametrize(
+    ("body", "expected"),
+    [
+        # Every one of these compiles fine and then raises
+        # "NameError: name '_unpack_sequence_' is not defined" at call time when
+        # the guard is missing from the sandbox globals.
+        ("    a, b = inputs['pair']\n    return a + b\n", 3),
+        ("    a, (b, c) = inputs['nested']\n    return a + b + c\n", 6),
+        ("    a, *rest = inputs['seq']\n    return rest\n", [2, 3]),
+        ("    with inputs['ctx'] as (a, b):\n        return a + b\n", 15),
+    ],
+)
+def test_tuple_unpacking_runs(body: str, expected):
+    """Ordinary tuple unpacking must work inside a guardrail, not NameError."""
+
+    class _Ctx:
+        def __enter__(self):
+            return (7, 8)
+
+        def __exit__(self, *args):
+            return False
+
+    guardrail = _compile("def apply_guardrail(inputs, request_data, input_type):\n" + body)
+    fn = guardrail._compiled_function
+    assert fn is not None
+    inputs = {"pair": (1, 2), "nested": (1, (2, 3)), "seq": [1, 2, 3], "ctx": _Ctx()}
+    assert fn(inputs, {}, "request") == expected