diff --git a/litellm/litellm_core_utils/streaming_handler.py b/litellm/litellm_core_utils/streaming_handler.py
index 96e70845b28..7303c8c6c05 100644
--- a/litellm/litellm_core_utils/streaming_handler.py
+++ b/litellm/litellm_core_utils/streaming_handler.py
@@ -2090,7 +2090,7 @@ class CustomStreamWrapper:
                     ):
                         chunk = self.completion_stream
                     else:
-                        chunk = next(self.completion_stream)  # type: ignore[arg-type]
+                        chunk = await asyncio.to_thread(next, self.completion_stream)  # type: ignore[arg-type]
                     if chunk is not None and chunk != b"":
                         processed_chunk = self.chunk_creator(chunk=chunk)
                         if processed_chunk is None:
diff --git a/tests/test_litellm/litellm_core_utils/test_streaming_handler.py b/tests/test_litellm/litellm_core_utils/test_streaming_handler.py
index e0862629947..3c74d73288f 100644
--- a/tests/test_litellm/litellm_core_utils/test_streaming_handler.py
+++ b/tests/test_litellm/litellm_core_utils/test_streaming_handler.py
@@ -1679,3 +1679,78 @@ def test_tool_use_not_dropped_when_finish_reason_already_set(
     )
     assert tool_calls[0].id == "call_1"
     assert tool_calls[0].function.name == "get_weather"
+
+
+@pytest.mark.asyncio
+async def test_custom_stream_wrapper_anext_does_not_block_event_loop_for_sync_iterators(
+    logging_obj: Logging,
+):
+    """
+    Regression test: __anext__ must not call blocking next() on a sync iterator on the
+    event loop thread. This happens for some provider streams which are sync iterators
+    but used in async contexts (e.g. boto3-style streaming).
+    """
+
+    class BlockingIterator:
+        def __init__(self, chunks, delay_s: float):
+            self._it = iter(chunks)
+            self._delay_s = delay_s
+
+        def __iter__(self):
+            return self
+
+        def __next__(self):
+            time.sleep(self._delay_s)  # simulate blocking I/O
+            return next(self._it)
+
+    test_chunk = ModelResponseStream(
+        id="chatcmpl-test",
+        created=int(time.time()),
+        model="test-model",
+        object="chat.completion.chunk",
+        system_fingerprint=None,
+        choices=[
+            StreamingChoices(
+                finish_reason="stop",
+                index=0,
+                delta=Delta(
+                    provider_specific_fields=None,
+                    content="hello",
+                    role="assistant",
+                    function_call=None,
+                    tool_calls=None,
+                    audio=None,
+                ),
+                logprobs=None,
+            )
+        ],
+        provider_specific_fields={},
+        usage=None,
+    )
+
+    # Delay is intentionally > the wait_for timeout used to detect event loop blocking.
+    wrapper = CustomStreamWrapper(
+        completion_stream=BlockingIterator([test_chunk], delay_s=0.3),
+        model="test-model",
+        logging_obj=logging_obj,
+        custom_llm_provider="cached_response",
+    )
+
+    tick_event = asyncio.Event()
+
+    async def background_tick():
+        await asyncio.sleep(0.05)
+        tick_event.set()
+
+    bg_task = asyncio.create_task(background_tick())
+    anext_task = asyncio.create_task(wrapper.__anext__())
+    try:
+        # If the event loop is blocked by a sync next(), this will time out.
+        await asyncio.wait_for(tick_event.wait(), timeout=0.15)
+
+        out = await asyncio.wait_for(anext_task, timeout=2.0)
+        assert isinstance(out, ModelResponseStream)
+    finally:
+        if not anext_task.done():
+            anext_task.cancel()
+        await bg_task