diff --git a/litellm/proxy/proxy_server.py b/litellm/proxy/proxy_server.py
index 967cae27990..a7d7f9ca64f 100644
--- a/litellm/proxy/proxy_server.py
+++ b/litellm/proxy/proxy_server.py
@@ -7781,6 +7781,7 @@ class ProxyConfig:
                     verbose_proxy_logger.debug("_model_list: %s", _model_list)
                     llm_router = litellm.Router(
                         model_list=_model_list,
+                        cache_responses=litellm.cache is not None,
                         router_general_settings=RouterGeneralSettings(
                             async_only_mode=True  # only init async clients
                         ),
diff --git a/tests/unit/proxy/proxy_server/test_db_router_response_cache.py b/tests/unit/proxy/proxy_server/test_db_router_response_cache.py
new file mode 100644
index 00000000000..c2ee97c7bb5
--- /dev/null
+++ b/tests/unit/proxy/proxy_server/test_db_router_response_cache.py
@@ -0,0 +1,99 @@
+"""Regression coverage for response caching on DB-backed router creation."""
+
+import asyncio
+import importlib
+from unittest.mock import AsyncMock, MagicMock
+
+import litellm
+import pytest
+
+from litellm.proxy.proxy_server import ProxyConfig
+
+
+def _db_model() -> MagicMock:
+    record = MagicMock()
+    record.model_id = "db-id-1"
+    record.model_name = "fake-model"
+    record.litellm_params = {"model": "fake-model"}
+    record.model_info = {"id": "db-id-1"}
+    record.created_by = "default_user_id"
+    record.created_at = None
+    record.updated_at = None
+    record.updated_by = None
+    return record
+
+
+@pytest.mark.asyncio
+async def test_db_router_rebuild_serves_same_caller_from_cache_and_isolates_callers(monkeypatch):
+    """A DB router rebuild must use response caching without crossing caller boundaries."""
+    proxy_config = ProxyConfig()
+    fake_model_list = [
+        {
+            "model_name": "fake-model",
+            "litellm_params": {
+                "model": "openai/fake-model",
+                "api_key": "sk-fake",
+                "mock_response": "cached response",
+            },
+        }
+    ]
+    monkeypatch.setattr(litellm, "cache", litellm.Cache())
+    provider_calls = 0
+    litellm_main = importlib.import_module("litellm.main")
+    original_mock_completion = litellm_main.mock_completion
+
+    def tracked_mock_completion(*args, **kwargs):
+        nonlocal provider_calls
+        provider_calls += 1
+        return original_mock_completion(*args, **kwargs)
+
+    monkeypatch.setattr(litellm_main, "mock_completion", tracked_mock_completion)
+    monkeypatch.setattr("litellm.proxy.proxy_server.llm_router", None)
+    monkeypatch.setattr("litellm.proxy.proxy_server.master_key", "sk-test")
+    monkeypatch.setattr("litellm.proxy.proxy_server.llm_model_list", [])
+    monkeypatch.setattr("litellm.proxy.proxy_server.general_settings", {})
+    monkeypatch.setattr(proxy_config, "decrypt_model_list_from_db", lambda new_models: fake_model_list)
+    monkeypatch.setattr(proxy_config, "_add_router_settings_from_db_config", AsyncMock())
+
+    await proxy_config._update_llm_router(
+        new_models=[_db_model()],
+        proxy_logging_obj=MagicMock(),
+    )
+    router = __import__("litellm.proxy.proxy_server", fromlist=["llm_router"]).llm_router
+
+    request = [{"role": "user", "content": "cache canary"}]
+    first = await router.acompletion(model="fake-model", messages=request, user="caller-a")
+    await asyncio.sleep(1)
+    same_caller = await router.acompletion(model="fake-model", messages=request, user="caller-a")
+    other_caller = await router.acompletion(model="fake-model", messages=request, user="caller-b")
+
+    assert first.id == same_caller.id
+    assert first.id != other_caller.id
+    assert provider_calls == 2
+
+
+@pytest.mark.asyncio
+async def test_db_router_rebuild_keeps_cache_disabled_without_global_cache(monkeypatch):
+    """The DB router must not enable response caching when the proxy has no cache."""
+    proxy_config = ProxyConfig()
+    fake_model_list = [
+        {
+            "model_name": "fake-model",
+            "litellm_params": {"model": "openai/fake-model", "api_key": "sk-fake"},
+        }
+    ]
+    monkeypatch.setattr(litellm, "cache", None)
+    monkeypatch.setattr("litellm.proxy.proxy_server.llm_router", None)
+    monkeypatch.setattr("litellm.proxy.proxy_server.master_key", "sk-test")
+    monkeypatch.setattr("litellm.proxy.proxy_server.llm_model_list", [])
+    monkeypatch.setattr("litellm.proxy.proxy_server.general_settings", {})
+    monkeypatch.setattr(proxy_config, "decrypt_model_list_from_db", lambda new_models: fake_model_list)
+    monkeypatch.setattr(proxy_config, "_add_router_settings_from_db_config", AsyncMock())
+
+    await proxy_config._update_llm_router(
+        new_models=[_db_model()],
+        proxy_logging_obj=MagicMock(),
+    )
+    router = __import__("litellm.proxy.proxy_server", fromlist=["llm_router"]).llm_router
+
+    assert router.cache_responses is False