diff --git a/litellm/caching/caching_handler.py b/litellm/caching/caching_handler.py
index e924d829bfa..1d06b6804fc 100644
--- a/litellm/caching/caching_handler.py
+++ b/litellm/caching/caching_handler.py
@@ -154,9 +154,13 @@ def _content_block_payload(event: Mapping[str, object]) -> object:
             return None
 
 
+def _is_blank(value: object) -> bool:
+    return value in ("", [], {}, None) or (isinstance(value, str) and not value.strip())
+
+
 def _content_block_carries_output(block: object) -> bool:
     fields: Final = as_str_mapping(block)
-    return fields is not None and any(key != "type" and value not in ("", [], None) for key, value in fields.items())
+    return fields is not None and any(key != "type" and not _is_blank(value) for key, value in fields.items())
 
 
 def _sse_line_carries_output(line: str) -> bool:
@@ -178,12 +182,9 @@ def _message_field_carries_output(key: str, value: object) -> bool:
             return False
         case "provider_specific_fields":
             fields: Final = as_str_mapping(value) or {}
-            return any(
-                name not in _REPLAY_METADATA_FIELDS and field not in ("", [], {}, None)
-                for name, field in fields.items()
-            )
+            return any(name not in _REPLAY_METADATA_FIELDS and not _is_blank(field) for name, field in fields.items())
         case _:
-            return value not in ("", [], {}, None)
+            return not _is_blank(value)
 
 
 def _choice_output_fields(choice: object) -> Mapping[str, object]:
diff --git a/tests/unit/caching/test_caching_handler.py b/tests/unit/caching/test_caching_handler.py
index 5479087013a..2b7d7fa0e14 100644
--- a/tests/unit/caching/test_caching_handler.py
+++ b/tests/unit/caching/test_caching_handler.py
@@ -2765,6 +2765,10 @@ def _anthropic_message_with_only_an_empty_text_block() -> dict[str, object]:
     }
 
 
+def _anthropic_message_with_only_a_whitespace_text_block() -> dict[str, object]:
+    return {**_anthropic_message_with_only_an_empty_text_block(), "content": [{"type": "text", "text": "\n\n"}]}
+
+
 def _empty_reply_with_provider_metadata(provider_specific_fields: dict[str, object]) -> ModelResponse:
     return litellm.ModelResponse(
         choices=[litellm.Choices(message=litellm.Message(content="", provider_specific_fields=provider_specific_fields))]
@@ -2846,6 +2850,18 @@ def _empty_response_cases() -> list[EmptyResponseCase]:
             CallTypes.aanthropic_messages.value,
             {"messages": _unique_messages(), "max_tokens": 16},
         ),
+        (
+            _anthropic_message_with_only_a_whitespace_text_block(),
+            aanthropic_messages,
+            CallTypes.aanthropic_messages.value,
+            {"messages": _unique_messages(), "max_tokens": 16},
+        ),
+        (
+            litellm.ModelResponse(choices=[litellm.Choices(message=litellm.Message(content="\n\n"))]),
+            litellm.acompletion,
+            CallTypes.acompletion.value,
+            {"messages": _unique_messages()},
+        ),
         (
             _empty_reply_with_provider_metadata({"thought_signatures": ["c2lnbmF0dXJl"]}),
             litellm.acompletion,
@@ -2897,6 +2913,15 @@ def _empty_response_cases() -> list[EmptyResponseCase]:
             CallTypes.aanthropic_messages.value,
             {"messages": _unique_messages(), "max_tokens": 16, "stream": True},
         ),
+        (
+            _anthropic_stream_with_only_empty_blocks(
+                {"type": "content_block_start", "index": 0, "content_block": {"type": "text", "text": ""}},
+                {"type": "content_block_delta", "index": 0, "delta": {"type": "text_delta", "text": "\n\n"}},
+            ),
+            aanthropic_messages,
+            CallTypes.aanthropic_messages.value,
+            {"messages": _unique_messages(), "max_tokens": 16, "stream": True},
+        ),
     ]
 
 
@@ -2951,6 +2976,28 @@ async def test_async_get_cache_treats_stored_response_without_output_as_miss(
     assert lookup.cached_result is None
 
 
+@pytest.mark.asyncio
+async def test_async_set_cache_keeps_reply_whose_text_is_padded_with_whitespace():
+    setup_cache()
+    handler: Final = LLMCachingHandler(original_function=litellm.acompletion, request_kwargs={}, start_time=_FIXED_START)
+    kwargs: Final = {"messages": _unique_messages()}
+    reply: Final = litellm.ModelResponse(choices=[litellm.Choices(message=litellm.Message(content="\n\nParis\n"))])
+
+    await handler.async_set_cache(result=reply, original_function=litellm.acompletion, kwargs=kwargs)
+    await asyncio.gather(*_PENDING_CACHE_WRITES)
+    lookup: Final = await handler.async_get_cache(
+        model="gpt-3.5-turbo",
+        original_function=litellm.acompletion,
+        logging_obj=_completion_logging_obj(CallTypes.acompletion.value),
+        start_time=_FIXED_START,
+        call_type=CallTypes.acompletion.value,
+        kwargs=kwargs,
+    )
+
+    assert isinstance(lookup.cached_result, ModelResponse)
+    assert lookup.cached_result.choices[0].message.content == "\n\nParis\n"
+
+
 @pytest.mark.asyncio
 async def test_async_get_cache_heals_stored_completion_without_choices():
     setup_cache()