diff --git a/litellm/litellm_core_utils/streaming_handler.py b/litellm/litellm_core_utils/streaming_handler.py
index ccd5c1dd8f5..a7c4a4d3491 100644
--- a/litellm/litellm_core_utils/streaming_handler.py
+++ b/litellm/litellm_core_utils/streaming_handler.py
@@ -96,6 +96,7 @@ class CustomStreamWrapper:
         self.completion_stream = completion_stream
         self.sent_first_chunk = False
         self.sent_last_chunk = False
+        self._stream_created_time: float = time.time()
 
         litellm_params: GenericLiteLLMParams = GenericLiteLLMParams(
             **self.logging_obj.model_call_details.get("litellm_params", {})
@@ -161,6 +162,20 @@ class CustomStreamWrapper:
         self.is_function_call = self.check_is_function_call(logging_obj=logging_obj)
         self.created: Optional[int] = None
 
+    def _check_max_streaming_duration(self) -> None:
+        """Raise litellm.Timeout if the stream has exceeded MAX_STREAMING_CHUNK_DURATION_S."""
+        from litellm.constants import MAX_STREAMING_CHUNK_DURATION_S
+
+        if MAX_STREAMING_CHUNK_DURATION_S is None:
+            return
+        elapsed = time.time() - self._stream_created_time
+        if elapsed > MAX_STREAMING_CHUNK_DURATION_S:
+            raise litellm.Timeout(
+                message=f"Stream exceeded max streaming duration of {MAX_STREAMING_CHUNK_DURATION_S}s (elapsed {elapsed:.1f}s)",
+                model=self.model or "",
+                llm_provider=self.custom_llm_provider or "",
+            )
+
     def __iter__(self) -> Iterator["ModelResponseStream"]:
         return self
 
@@ -1743,6 +1758,7 @@ class CustomStreamWrapper:
             and self.custom_llm_provider == "cached_response"
         ):
             cache_hit = True
+        self._check_max_streaming_duration()
         try:
             if self.completion_stream is None:
                 self.fetch_sync_stream()
@@ -1917,6 +1933,7 @@ class CustomStreamWrapper:
             and self.custom_llm_provider == "cached_response"
         ):
             cache_hit = True
+        self._check_max_streaming_duration()
         try:
             if self.completion_stream is None:
                 await self.fetch_stream()
diff --git a/litellm/responses/streaming_iterator.py b/litellm/responses/streaming_iterator.py
index edcbb0d11b8..034e1e91a50 100644
--- a/litellm/responses/streaming_iterator.py
+++ b/litellm/responses/streaming_iterator.py
@@ -1,5 +1,6 @@
 import asyncio
 import json
+import time
 import traceback
 from datetime import datetime
 from typing import Any, Dict, Optional
@@ -7,7 +8,7 @@ from typing import Any, Dict, Optional
 import httpx
 
 import litellm
-from litellm.constants import STREAM_SSE_DONE_STRING
+from litellm.constants import MAX_STREAMING_CHUNK_DURATION_S, STREAM_SSE_DONE_STRING
 from litellm.litellm_core_utils.asyncify import run_async_function
 from litellm.litellm_core_utils.core_helpers import process_response_headers
 from litellm.litellm_core_utils.litellm_logging import Logging as LiteLLMLoggingObj
@@ -56,6 +57,7 @@ class BaseResponsesAPIStreamingIterator:
         self.completed_response: Optional[ResponsesAPIStreamingResponse] = None
         self.start_time = getattr(logging_obj, "start_time", datetime.now())
         self._failure_handled = False  # Track if failure handler has been called
+        self._stream_created_time: float = time.time()
 
         # track request context for hooks
         self.litellm_metadata = litellm_metadata
@@ -82,6 +84,18 @@ class BaseResponsesAPIStreamingIterator:
             self.response.headers or {}
         )  # GUARANTEE OPENAI HEADERS IN RESPONSE
 
+    def _check_max_streaming_duration(self) -> None:
+        """Raise litellm.Timeout if the stream has exceeded MAX_STREAMING_CHUNK_DURATION_S."""
+        if MAX_STREAMING_CHUNK_DURATION_S is None:
+            return
+        elapsed = time.time() - self._stream_created_time
+        if elapsed > MAX_STREAMING_CHUNK_DURATION_S:
+            raise litellm.Timeout(
+                message=f"Stream exceeded max streaming duration of {MAX_STREAMING_CHUNK_DURATION_S}s (elapsed {elapsed:.1f}s)",
+                model=self.model or "",
+                llm_provider=self.custom_llm_provider or "",
+            )
+
     def _process_chunk(self, chunk) -> Optional[ResponsesAPIStreamingResponse]:
         """Process a single chunk of data from the stream"""
         if not chunk:
@@ -357,6 +371,7 @@ class ResponsesAPIStreamingIterator(BaseResponsesAPIStreamingIterator):
 
     async def __anext__(self) -> ResponsesAPIStreamingResponse:
         try:
+            self._check_max_streaming_duration()
             while True:
                 # Get the next chunk from the stream
                 try:
@@ -365,6 +380,7 @@ class ResponsesAPIStreamingIterator(BaseResponsesAPIStreamingIterator):
                     self.finished = True
                     raise StopAsyncIteration
 
+                self._check_max_streaming_duration()
                 result = self._process_chunk(chunk)
 
                 if self.finished: