diff --git a/tests/pass_through_unit_tests/test_bedrock_tool_use_beta_header.py b/tests/pass_through_unit_tests/test_bedrock_tool_use_beta_header.py
new file mode 100644
index 00000000000..635ace016fe
--- /dev/null
+++ b/tests/pass_through_unit_tests/test_bedrock_tool_use_beta_header.py
@@ -0,0 +1,69 @@
+"""
+Simple E2E test for Bedrock with advanced-tool-use beta header.
+
+Tests that LiteLLM correctly filters out the advanced-tool-use-2025-11-20 beta header
+for Bedrock Invoke API, which doesn't support it and returns a 400 "invalid beta flag" error.
+"""
+import os
+import sys
+import pytest
+
+sys.path.insert(0, os.path.abspath("../.."))
+
+import litellm
+
+
+@pytest.mark.asyncio
+async def test_bedrock_sonnet_4_5_with_advanced_tool_use_beta_header():
+    """
+    Simple E2E test: Call Bedrock Sonnet 4.5 with advanced-tool-use beta header.
+
+    This should work without throwing "invalid beta flag" error because LiteLLM
+    filters out the advanced-tool-use beta header for Bedrock Invoke API.
+    """
+    litellm._turn_on_debug()
+    response = await litellm.anthropic.messages.acreate(
+        model="bedrock/invoke/us.anthropic.claude-sonnet-4-5-20250929-v1:0",
+        messages=[{"role": "user", "content": "What is 2+2?"}],
+        max_tokens=100,
+        provider_specific_header={
+            "custom_llm_provider": "bedrock",
+            "extra_headers": {
+                "anthropic-beta": "advanced-tool-use-2025-11-20",
+            },
+        },
+    )
+
+    # Verify response
+    assert response is not None
+    assert "content" in response
+    print(f"✅ Test passed! Response: {response}")
+
+
+@pytest.mark.asyncio
+async def test_bedrock_claude_3_5_with_advanced_tool_use_beta_header_filtered():
+    """
+    Simple E2E test: Call Bedrock Claude 3.5 with advanced-tool-use beta header.
+
+    This should work because the beta header is filtered out by LiteLLM before
+    sending the request to Bedrock Invoke API.
+    """
+
+    response = await litellm.anthropic.messages.acreate(
+        model="bedrock/invoke/us.anthropic.claude-3-5-sonnet-20240620-v1:0",
+        messages=[{"role": "user", "content": "What is 2+2?"}],
+        max_tokens=100,
+        provider_specific_header={
+            "custom_llm_provider": "bedrock",
+            "extra_headers": {
+                "anthropic-beta": "advanced-tool-use-2025-11-20",
+            },
+        },
+    )
+
+    # Verify response
+    assert response is not None
+    assert "content" in response
+    print(f"✅ Test passed! Claude 3.5 response (beta header filtered): {response}")
+
+