diff --git a/.github/workflows/mutation-test.yml b/.github/workflows/mutation-test.yml
new file mode 100644
index 00000000000..a713d2045be
--- /dev/null
+++ b/.github/workflows/mutation-test.yml
@@ -0,0 +1,102 @@
+name: "Mutation Test (manual)"
+
+# Smoke test for mutation testing. Manually triggered only — never on PR/push.
+# Runs mutmut against the scope configured in [tool.mutmut] in pyproject.toml
+# (currently a single file, ~186 LOC). Expected runtime: ~5-15 minutes.
+#
+# Uploads the mutmut cache + a text summary as a workflow artifact. Failures
+# do not block anything because nothing depends on this workflow.
+
+on:
+  workflow_dispatch:
+  # TEMPORARY: lets us iterate on this workflow before it lands on the default
+  # branch (workflow_dispatch only works once the file is on default). Remove
+  # this push: block before merging — final state should be workflow_dispatch
+  # only.
+  push:
+    branches:
+      - litellm_mutation_test_smoke
+
+permissions:
+  contents: read
+
+concurrency:
+  group: mutation-test-${{ github.ref }}
+  cancel-in-progress: true
+
+jobs:
+  mutation:
+    name: Run mutmut
+    runs-on: ubuntu-latest
+    timeout-minutes: 60
+
+    steps:
+      - uses: actions/checkout@08eba0b27e820071cde6df949e0beb9ba4906955 # v4.3.0
+        with:
+          persist-credentials: false
+
+      - name: Set up Python
+        uses: actions/setup-python@a26af69be951a213d495a4c3e4e4022e16d87065 # v5.6.0
+        with:
+          python-version: "3.12"
+
+      - name: Set up uv
+        uses: astral-sh/setup-uv@37802adc94f370d6bfd71619e3f0bf239e1f3b78 # v7
+        with:
+          version: "0.10.9"
+
+      - name: Cache uv dependencies
+        uses: actions/cache@0057852bfaa89a56745cba8c7296529d2fc39830 # v4.3.0
+        with:
+          path: |
+            ~/.cache/uv
+            .venv
+          key: ${{ runner.os }}-uv-${{ hashFiles('uv.lock') }}
+          restore-keys: |
+            ${{ runner.os }}-uv-
+
+      - name: Install dependencies
+        run: |
+          uv sync --frozen --group ci --group proxy-dev --extra google --extra proxy --extra semantic-router
+
+      - name: Generate Prisma client
+        env:
+          PRISMA_BINARY_CACHE_DIR: ${{ runner.temp }}/prisma-cache
+        run: |
+          uv run --no-sync prisma generate --schema litellm/proxy/schema.prisma
+
+      # mutmut 3.x runs tests inside a `mutants/` sandbox where it injects
+      # mutation trampolines. uv installs the project as editable by default,
+      # which puts the original source dir on sys.path via a .pth file and
+      # shadows the sandbox copy — so tests would never exercise the mutated
+      # code. Reinstalling non-editable removes the .pth shadow.
+      - name: Reinstall litellm non-editable (so mutants/ is not shadowed)
+        run: |
+          uv pip uninstall litellm
+          uv pip install . --no-deps
+
+      - name: Run mutmut
+        env:
+          # Make the mutants/ sandbox win over site-packages on sys.path so the
+          # trampolined files are imported instead of the installed copy.
+          PYTHONPATH: ${{ github.workspace }}/mutants
+        run: |
+          mkdir -p mutants
+          uv run --no-sync --with mutmut==3.5.0 mutmut run
+
+      - name: Show mutmut results
+        if: always()
+        run: |
+          uv run --no-sync --with mutmut==3.5.0 mutmut results | tee mutmut-results.txt
+
+      - name: Upload mutmut artifacts
+        if: always()
+        uses: actions/upload-artifact@4cec3d8aa04e39d1a68397de0c4cd6fb9dce8ec1 # v4.6.1
+        with:
+          name: mutmut-${{ github.run_id }}-${{ github.run_attempt }}
+          path: |
+            mutmut-results.txt
+            mutmut-stats.json
+            mutmut-cache.json
+          if-no-files-found: warn
+          retention-days: 14
diff --git a/pyproject.toml b/pyproject.toml
index 5cd83148d37..1a5a3e8fd2c 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -275,6 +275,22 @@ filterwarnings = [
     "ignore::DeprecationWarning:pytest_asyncio.plugin",
 ]
 
+[tool.mutmut]
+# Mutation-testing scope. Driven by the manually-triggered workflow at
+# .github/workflows/mutation-test.yml. mutmut is not part of the project's
+# default install; it is pulled in via `uv run --with mutmut==<version>` in CI.
+# `also_copy = ["litellm/"]` is required because mutmut runs in a `mutants/`
+# sandbox and the test conftest imports from across the litellm package.
+paths_to_mutate = [
+    "litellm/proxy/management_endpoints/router_settings_endpoints.py",
+]
+tests_dir = [
+    "tests/test_litellm/proxy/management_endpoints/test_router_settings_endpoints.py",
+]
+also_copy = [
+    "litellm/",
+]
+
 [tool.coverage.run]
 source = ["litellm"]
 relative_files = true