diff --git a/litellm/vector_stores/vector_store_registry.py b/litellm/vector_stores/vector_store_registry.py
index 22d27bc3266..e8dd246a5cc 100644
--- a/litellm/vector_stores/vector_store_registry.py
+++ b/litellm/vector_stores/vector_store_registry.py
@@ -104,6 +104,7 @@ class VectorStoreRegistry:
     def __init__(self, vector_stores: list[LiteLLM_ManagedVectorStore] = []):
         self.vector_stores: list[LiteLLM_ManagedVectorStore] = vector_stores
         self.vector_store_ids_to_vector_store_map: dict[str, LiteLLM_ManagedVectorStore] = {}
+        self.config_vector_store_ids: frozenset[str] = frozenset()
 
     def _extract_tool_params(self, tool: dict) -> VectorStoreToolParams:
         """
@@ -338,8 +339,13 @@ class VectorStoreRegistry:
                     break
 
             # Verify vector store still exists in database (if we have DB access)
-            # This ensures deleted vector stores are removed from cache
-            if vector_store is not None and prisma_client is not None:
+            # This ensures deleted vector stores are removed from cache.
+            # Config-defined vector stores are never in the database, so skip the check for them
+            if (
+                vector_store is not None
+                and prisma_client is not None
+                and vector_store_id not in self.config_vector_store_ids
+            ):
                 try:
                     # Check if it still exists in database
                     db_vector_store = await ManagedVectorStoresRepository(prisma_client).table.find_unique(
@@ -427,6 +433,7 @@ class VectorStoreRegistry:
                 updated_at=datetime.now(timezone.utc),
             )
             self.vector_stores.append(litellm_managed_vector_store)
+            self.config_vector_store_ids = self.config_vector_store_ids | {vector_store_id}
 
         verbose_logger.debug(
             "all loaded vector stores = %s",
diff --git a/tests/test_litellm/vector_stores/test_vector_store_registry.py b/tests/test_litellm/vector_stores/test_vector_store_registry.py
index f19c3706845..84e59d424fa 100644
--- a/tests/test_litellm/vector_stores/test_vector_store_registry.py
+++ b/tests/test_litellm/vector_stores/test_vector_store_registry.py
@@ -8,7 +8,7 @@ from fastapi.testclient import TestClient
 
 
 from datetime import datetime, timezone
-from unittest.mock import MagicMock
+from unittest.mock import AsyncMock, MagicMock
 
 import litellm
 from litellm.types.vector_stores import LiteLLM_ManagedVectorStore
@@ -182,3 +182,39 @@ def test_search_uses_registry_credentials():
             assert getattr(called_params, "aws_region_name") == "us-east-1"
     finally:
         litellm.vector_store_registry = original_registry
+
+
+@pytest.mark.asyncio
+async def test_config_vector_store_survives_db_check():
+    """Config-defined vector stores are not in the DB and must not be evicted when a DB is connected."""
+    registry = VectorStoreRegistry()
+    registry.load_vector_stores_from_config(
+        [
+            {
+                "vector_store_name": "config-kb",
+                "litellm_params": {
+                    "vector_store_id": "CONFIGKB",
+                    "custom_llm_provider": "bedrock",
+                },
+            }
+        ]
+    )
+
+    db_store = LiteLLM_ManagedVectorStore(
+        vector_store_id="DBONLY",
+        custom_llm_provider="bedrock",
+        created_at=datetime.now(timezone.utc),
+        updated_at=datetime.now(timezone.utc),
+    )
+    registry.add_vector_store_to_registry(db_store)
+
+    mock_prisma_client = MagicMock()
+    mock_prisma_client.db.litellm_managedvectorstorestable.find_unique = AsyncMock(return_value=None)
+    result = await registry.pop_vector_stores_to_run_with_db_fallback(
+        non_default_params={"vector_store_ids": ["CONFIGKB", "DBONLY"]},
+        prisma_client=mock_prisma_client,
+    )
+
+    assert [vs.get("vector_store_id") for vs in result] == ["CONFIGKB"]
+    assert any(vs.get("vector_store_id") == "CONFIGKB" for vs in registry.vector_stores)
+    assert not any(vs.get("vector_store_id") == "DBONLY" for vs in registry.vector_stores)