diff --git a/litellm/utils.py b/litellm/utils.py
index ed0d6ee930d..85aa9acc2d8 100644
--- a/litellm/utils.py
+++ b/litellm/utils.py
@@ -2075,6 +2075,7 @@ def _is_async_request(
         or kwargs.get("_arealtime", False) is True
         or kwargs.get("acreate_batch", False) is True
         or kwargs.get("acreate_fine_tuning_job", False) is True
+        or kwargs.get("acreate_file", False) is True
         or is_pass_through is True
     ):
         return True
diff --git a/test_acreate_file_fix.py b/test_acreate_file_fix.py
new file mode 100644
index 00000000000..10417651a9e
--- /dev/null
+++ b/test_acreate_file_fix.py
@@ -0,0 +1,88 @@
+#!/usr/bin/env python3
+"""
+Test script to verify the acreate_file RuntimeWarning fix.
+This reproduces the issue described in GitHub issue #20798.
+"""
+import asyncio
+import warnings
+import os
+import tempfile
+
+# Capture warnings
+warnings.simplefilter("always")
+
+# Add the project to path
+import sys
+sys.path.insert(0, '/tmp/oss-litellm')
+
+import litellm
+from litellm.utils import _is_async_request
+
+
+async def test_acreate_file_async_detection():
+    """Test that _is_async_request properly detects acreate_file calls."""
+    print("Testing _is_async_request function...")
+    
+    # Test kwargs similar to what acreate_file sets
+    test_kwargs = {"acreate_file": True}
+    result = _is_async_request(test_kwargs)
+    
+    print(f"_is_async_request with acreate_file=True returned: {result}")
+    assert result is True, "Expected _is_async_request to return True for acreate_file=True"
+    print("✅ _is_async_request correctly detects acreate_file!")
+
+
+async def test_acreate_file_mock():
+    """Test acreate_file to ensure no runtime warnings are generated."""
+    print("\nTesting acreate_file function...")
+    
+    # Create a temporary file for testing
+    with tempfile.NamedTemporaryFile(mode='w', suffix='.txt', delete=False) as f:
+        f.write("Hello, World! This is a test file.")
+        temp_file_path = f.name
+    
+    try:
+        # Note: This will fail because we don't have valid API keys
+        # but it should NOT generate a RuntimeWarning about coroutines
+        try:
+            with warnings.catch_warnings(record=True) as w:
+                warnings.simplefilter("always")
+                
+                result = await litellm.acreate_file(
+                    file=open(temp_file_path, "rb"),
+                    purpose="assistants",
+                    api_key="test-key",  # Mock key
+                )
+        except Exception as e:
+            print(f"Expected exception (no valid API key): {type(e).__name__}")
+            
+            # Check if any RuntimeWarnings about coroutines were captured
+            runtime_warnings = [warn for warn in w if issubclass(warn.category, RuntimeWarning)]
+            coroutine_warnings = [warn for warn in runtime_warnings if "coroutine" in str(warn.message)]
+            
+            if coroutine_warnings:
+                print("❌ Found RuntimeWarnings about coroutines:")
+                for warn in coroutine_warnings:
+                    print(f"  {warn.message}")
+                assert False, "RuntimeWarning about coroutines found!"
+            else:
+                print("✅ No RuntimeWarning about coroutines detected!")
+                
+    finally:
+        # Clean up temp file
+        os.unlink(temp_file_path)
+
+
+async def main():
+    print("Testing GitHub Issue #20798 fix: acreate_file RuntimeWarning")
+    print("=" * 60)
+    
+    await test_acreate_file_async_detection()
+    await test_acreate_file_mock()
+    
+    print("\n" + "=" * 60)
+    print("✅ All tests passed! The fix appears to be working correctly.")
+
+
+if __name__ == "__main__":
+    asyncio.run(main())
\ No newline at end of file
diff --git a/test_simple_fix.py b/test_simple_fix.py
new file mode 100644
index 00000000000..f374624570d
--- /dev/null
+++ b/test_simple_fix.py
@@ -0,0 +1,110 @@
+#!/usr/bin/env python3
+"""
+Simple test to verify the _is_async_request fix without full dependencies.
+"""
+import sys
+import os
+
+# Read the utils.py file directly to test the function
+with open('/tmp/oss-litellm/litellm/utils.py', 'r') as f:
+    content = f.read()
+
+def test_function_contains_fix():
+    """Test that the _is_async_request function contains our fix."""
+    print("Testing that _is_async_request function contains acreate_file check...")
+    
+    # Find the _is_async_request function
+    start_marker = "def _is_async_request("
+    start_idx = content.find(start_marker)
+    
+    if start_idx == -1:
+        print("❌ Could not find _is_async_request function!")
+        return False
+    
+    # Find the end of the function (next def or end of file)
+    end_idx = content.find("\ndef ", start_idx + 1)
+    if end_idx == -1:
+        end_idx = len(content)
+    
+    function_content = content[start_idx:end_idx]
+    
+    # Check if our fix is present
+    if 'kwargs.get("acreate_file", False) is True' in function_content:
+        print("✅ Found acreate_file check in _is_async_request function!")
+        
+        # Also verify it's in the right place (in the if statement)
+        if_section_start = function_content.find("if (")
+        if_section_end = function_content.find("):", if_section_start)
+        if_section = function_content[if_section_start:if_section_end]
+        
+        if 'kwargs.get("acreate_file", False) is True' in if_section:
+            print("✅ acreate_file check is properly placed in the if condition!")
+            return True
+        else:
+            print("❌ acreate_file check found but not in the if condition!")
+            return False
+    else:
+        print("❌ acreate_file check NOT found in _is_async_request function!")
+        return False
+
+def test_function_logic():
+    """Test the logic of the fixed function manually."""
+    print("\nTesting _is_async_request function logic...")
+    
+    # Extract and test the function logic manually
+    test_cases = [
+        ({"acreate_file": True}, True, "acreate_file=True should return True"),
+        ({"acreate_file": False}, False, "acreate_file=False should return False"),
+        ({"acompletion": True}, True, "acompletion=True should return True"),
+        ({"some_other_key": True}, False, "unrelated key should return False"),
+        ({}, False, "empty dict should return False"),
+        (None, False, "None should return False"),
+    ]
+    
+    for kwargs, expected, description in test_cases:
+        # Manually test the logic based on what we see in the function
+        if kwargs is None:
+            result = False
+        elif (
+            kwargs.get("acompletion", False) is True
+            or kwargs.get("aembedding", False) is True
+            or kwargs.get("aimg_generation", False) is True
+            or kwargs.get("amoderation", False) is True
+            or kwargs.get("atext_completion", False) is True
+            or kwargs.get("atranscription", False) is True
+            or kwargs.get("arerank", False) is True
+            or kwargs.get("_arealtime", False) is True
+            or kwargs.get("acreate_batch", False) is True
+            or kwargs.get("acreate_fine_tuning_job", False) is True
+            or kwargs.get("acreate_file", False) is True  # Our fix!
+        ):
+            result = True
+        else:
+            result = False
+        
+        if result == expected:
+            print(f"✅ {description}")
+        else:
+            print(f"❌ {description} - got {result}, expected {expected}")
+            return False
+    
+    return True
+
+def main():
+    print("Testing GitHub Issue #20798 fix")
+    print("=" * 50)
+    
+    success1 = test_function_contains_fix()
+    success2 = test_function_logic()
+    
+    print("\n" + "=" * 50)
+    if success1 and success2:
+        print("✅ All tests passed! The fix is correctly implemented.")
+        return True
+    else:
+        print("❌ Some tests failed!")
+        return False
+
+if __name__ == "__main__":
+    success = main()
+    sys.exit(0 if success else 1)
\ No newline at end of file