diff --git a/litellm/llms/bedrock/common_utils.py b/litellm/llms/bedrock/common_utils.py
index cb2c70e74c8..1162a1c4375 100644
--- a/litellm/llms/bedrock/common_utils.py
+++ b/litellm/llms/bedrock/common_utils.py
@@ -1133,6 +1133,10 @@ class BedrockModelInfo(BaseLLMModelInfo):
             "agentcore/": "agentcore",
             "async_invoke/": "async_invoke",
             "openai/": "openai",
+            "global.openai.": "openai",
+            "eu.openai.": "openai",
+            "apac.openai.": "openai",
+            "us.openai.": "openai",
             "mantle/": "mantle",
         }
 
@@ -1257,7 +1261,13 @@ class BedrockModelInfo(BaseLLMModelInfo):
         Check if the model is an explicit openai route.
         Used for Bedrock imported models that use OpenAI Chat Completions format.
         """
-        return BedrockModelInfo._model_has_route_prefix(model, "openai/")
+        return (
+            BedrockModelInfo._model_has_route_prefix(model, "openai/")
+            or BedrockModelInfo._model_has_route_prefix(model, "global.openai.")
+            or BedrockModelInfo._model_has_route_prefix(model, "eu.openai.")
+            or BedrockModelInfo._model_has_route_prefix(model, "apac.openai.")
+            or BedrockModelInfo._model_has_route_prefix(model, "us.openai.")
+        )
 
     @staticmethod
     def get_bedrock_provider_config_for_messages_api(
diff --git a/tests/test_litellm/llms/bedrock/test_bedrock_common_utils.py b/tests/test_litellm/llms/bedrock/test_bedrock_common_utils.py
index a8a21e2cd37..4d402c86415 100644
--- a/tests/test_litellm/llms/bedrock/test_bedrock_common_utils.py
+++ b/tests/test_litellm/llms/bedrock/test_bedrock_common_utils.py
@@ -927,3 +927,58 @@ def test_every_bedrock_config_get_error_class_keeps_provider_headers(config):
 
 def test_bedrock_get_error_class_audit_covers_every_surface():
     assert len(_bedrock_configs_with_get_error_class()) >= 30
+
+
+@pytest.mark.parametrize(
+    "model",
+    [
+        "bedrock/global.openai.gpt-5.6-sol",
+        "bedrock/global.openai.gpt-5.6-terra",
+        "bedrock/global.openai.gpt-5.6-luna",
+        "bedrock/eu.openai.gpt-5.6-sol",
+        "bedrock/eu.openai.gpt-5.6-terra",
+        "bedrock/eu.openai.gpt-5.6-luna",
+        "bedrock/apac.openai.gpt-5.6-sol",
+        "bedrock/apac.openai.gpt-5.6-terra",
+        "bedrock/apac.openai.gpt-5.6-luna",
+        "bedrock/us.openai.gpt-5.6-sol",
+        "bedrock/us.openai.gpt-5.6-terra",
+        "bedrock/us.openai.gpt-5.6-luna",
+    ],
+)
+
+
+def test_bedrock_cross_region_openai_routing(model: str):
+    """
+    Ensure cross-region OpenAI inference profiles on Bedrock route to the
+    OpenAI-compatible config instead of falling back to Bedrock Converse.
+    """
+    import litellm
+    from litellm.llms.bedrock.common_utils import get_bedrock_chat_config
+    
+    assert BedrockModelInfo.get_bedrock_route(model) == "openai"
+    assert BedrockModelInfo._explicit_openai_route(model) is True
+
+    config = get_bedrock_chat_config(model)
+    assert isinstance(config, litellm.AmazonBedrockOpenAIConfig)
+
+
+@pytest.mark.parametrize(
+    "model",
+    [
+        "bedrock/converse/global.openai.gpt-5.6-sol",
+        "bedrock/converse/eu.openai.gpt-5.6-terra",
+        "bedrock/converse/us.openai.gpt-5.6-luna",
+    ],
+)
+
+
+def test_explicit_converse_prefix_overrides_openai_routing(model: str):
+    """
+    Ensure that a user can still explicitly force the Converse API for an OpenAI model
+    by using the `converse/` prefix, which takes precedence in route_mappings.
+    """
+    from litellm.llms.bedrock.common_utils import BedrockModelInfo
+
+    # Verify the explicit prefix intercepts the routing before the openai mapping
+    assert BedrockModelInfo.get_bedrock_route(model) == "converse"
diff --git a/tests/test_litellm/llms/bedrock/test_cross_region_inference_profile_mapping.py b/tests/test_litellm/llms/bedrock/test_cross_region_inference_profile_mapping.py
index fda3c8ceb8f..6bb1df90f01 100644
--- a/tests/test_litellm/llms/bedrock/test_cross_region_inference_profile_mapping.py
+++ b/tests/test_litellm/llms/bedrock/test_cross_region_inference_profile_mapping.py
@@ -150,9 +150,9 @@ def test_proxy_cost_calculation_scenario():
 
 
 @pytest.mark.parametrize("profile", GPT_5_6_PROFILES, ids=lambda p: p.model_id)
-def test_bedrock_gpt_5_6_profiles_route_to_converse(profile, local_model_cost_map):
-    """GPT-5.6 is served by Converse on bedrock-runtime, never by Invoke."""
-    assert BedrockModelInfo.get_bedrock_route(f"bedrock/{profile.model_id}") == "converse"
+def test_bedrock_gpt_5_6_profiles_route_to_openai(profile, local_model_cost_map):
+    """GPT-5.6 is served by Openai on bedrock-runtime."""
+    assert BedrockModelInfo.get_bedrock_route(f"bedrock/{profile.model_id}") == "openai"
 
 
 def test_bedrock_gpt_5_6_above_272k_tier_applies_to_cost(local_model_cost_map):