diff --git a/.github/workflows/test-dependency-installs.yml b/.github/workflows/test-dependency-installs.yml
index c3d33cbcfe2..0a72e302ea8 100644
--- a/.github/workflows/test-dependency-installs.yml
+++ b/.github/workflows/test-dependency-installs.yml
@@ -108,7 +108,7 @@ jobs:
         mkdir -p /tmp/mcp-gate-reports
         for profile in core mcp proxy; do
           for mode in minimum locked; do
-            uv run --no-project --python 3.12 --with 'packaging==26.0' --with 'coverage==7.14.0' \
+            uv run --isolated --no-project --python 3.12 --with 'packaging==26.0' --with 'coverage==7.14.0' \
               coverage run --append --branch --source=tests/mcp_dependency_tests,tests/base_sdk_tests \
               tests/mcp_dependency_tests/runner.py check \
               --wheel "${wheel[0]}" --profile "$profile" --mode "$mode" \
@@ -135,9 +135,9 @@ jobs:
               tests/base_sdk_tests/check_base_sdk_install.py
           fi
         done
-        uv run --no-project --python 3.12 --with 'packaging==26.0' \
+        uv run --isolated --no-project --python 3.12 --with 'packaging==26.0' \
           --with 'pytest==9.0.3' --with 'pytest-cov==5.0.0' --with 'coverage==7.14.0' \
-          pytest tests/mcp_dependency_tests/test_runner.py \
+          python -m pytest tests/mcp_dependency_tests/test_runner.py \
           --cov=tests/mcp_dependency_tests \
           --cov=tests/base_sdk_tests --cov-append --cov-branch \
           --cov-report=xml:mcp-dependency-coverage.xml
diff --git a/tests/mcp_dependency_tests/README.md b/tests/mcp_dependency_tests/README.md
index 6323592e9d5..2d35082cffd 100644
--- a/tests/mcp_dependency_tests/README.md
+++ b/tests/mcp_dependency_tests/README.md
@@ -13,7 +13,7 @@ uv build --wheel --package litellm-proxy-extras --out-dir /tmp/mcp-wheels
 Use the root wheel's exact filename in this command. The environment path must not already exist:
 
 ```bash
-uv run --no-project --python 3.12 tests/mcp_dependency_tests/runner.py check \
+uv run --isolated --no-project --python 3.12 tests/mcp_dependency_tests/runner.py check \
   --wheel /tmp/mcp-wheels/litellm-1.103.0-cp310-abi3-linux_x86_64.whl \
   --profile mcp --mode locked --python 3.12 --environment /tmp/mcp2-dev
 ```
@@ -39,7 +39,7 @@ CI measures runner coverage during actual installs. It measures isolated wheel c
 Use CI's uv version (0.10.9). Set an absolute cutoff in `candidate.toml` consistent with the root dependency-age policy, review advisories, then run `lock` for each profile/mode with the newly built wheel:
 
 ```bash
-uv run --no-project --python 3.12 tests/mcp_dependency_tests/runner.py lock \
+uv run --isolated --no-project --python 3.12 tests/mcp_dependency_tests/runner.py lock \
   --wheel /tmp/mcp-wheels/litellm-1.103.0-cp310-abi3-linux_x86_64.whl \
   --profile mcp --mode locked
 ```