diff --git a/litellm/passthrough/utils.py b/litellm/passthrough/utils.py
index 8ae32d37a93..5dde13f0078 100644
--- a/litellm/passthrough/utils.py
+++ b/litellm/passthrough/utils.py
@@ -3,8 +3,26 @@ from urllib.parse import parse_qs
 
 import httpx
 
+from litellm._logging import verbose_logger
 from litellm.constants import PASS_THROUGH_HEADER_PREFIX
 
+# Headers that must not be overwritten via the x-pass- forwarding mechanism.
+# Includes standard credential/auth headers and protocol-level headers that
+# affect routing or message framing.
+_PASS_THROUGH_PROTECTED_HEADERS: frozenset = frozenset(
+    {
+        "authorization",
+        "api-key",
+        "x-api-key",
+        "x-goog-api-key",
+        "host",
+        "content-length",
+    }
+)
+
+# Header name prefix used to block AWS SigV4 signing headers from being overridden.
+_PASS_THROUGH_PROTECTED_HEADER_PREFIXES: tuple = ("x-amz-",)
+
 
 class BasePassthroughUtils:
     @staticmethod
@@ -57,13 +75,19 @@ class BasePassthroughUtils:
             headers = {**request_headers, **headers}
 
         # Process x-pass- prefixed headers (strip prefix and forward)
-        # Certain protocol-level and credential headers are excluded from this mechanism.
-        _PROTECTED_HEADERS = {"authorization", "api-key", "host", "content-length"}
+        # Credential and protocol-level headers are excluded from this mechanism.
         for header_name, header_value in request_headers.items():
             if header_name.lower().startswith(PASS_THROUGH_HEADER_PREFIX):
-                # Strip the 'x-pass-' prefix to get the actual header name
-                actual_header_name = header_name[len(PASS_THROUGH_HEADER_PREFIX) :]
-                if actual_header_name.lower() in _PROTECTED_HEADERS:
+                # Strip the 'x-pass-' prefix and normalize to lowercase
+                actual_header_name = header_name[len(PASS_THROUGH_HEADER_PREFIX) :].lower()
+                if actual_header_name in _PASS_THROUGH_PROTECTED_HEADERS or any(
+                    actual_header_name.startswith(p)
+                    for p in _PASS_THROUGH_PROTECTED_HEADER_PREFIXES
+                ):
+                    verbose_logger.debug(
+                        "x-pass- header %s maps to a protected header name; skipping",
+                        header_name,
+                    )
                     continue
                 headers[actual_header_name] = header_value
 
diff --git a/tests/test_litellm/proxy/pass_through_endpoints/test_vertex_passthrough_load_balancing.py b/tests/test_litellm/proxy/pass_through_endpoints/test_vertex_passthrough_load_balancing.py
index eb4749549c2..b6dd714a232 100644
--- a/tests/test_litellm/proxy/pass_through_endpoints/test_vertex_passthrough_load_balancing.py
+++ b/tests/test_litellm/proxy/pass_through_endpoints/test_vertex_passthrough_load_balancing.py
@@ -451,6 +451,60 @@ def test_forward_headers_from_request_x_pass_prefix():
     assert "x-pass-custom-header" not in result
 
 
+def test_forward_headers_from_request_protected_headers_not_overwritten():
+    """
+    Test that x-pass- headers whose stripped names resolve to credential or
+    protocol-level header names are silently dropped and do not overwrite
+    values already present in the outbound headers dict.
+    """
+    from litellm.passthrough.utils import BasePassthroughUtils
+
+    proxy_headers = {
+        "authorization": "Bearer proxy-upstream-key",
+        "api-key": "proxy-azure-key",
+        "x-api-key": "proxy-anthropic-key",
+        "x-goog-api-key": "proxy-google-key",
+    }
+
+    request_headers = {
+        "x-pass-authorization": "Bearer attacker-key",
+        "x-pass-api-key": "attacker-azure-key",
+        "x-pass-x-api-key": "attacker-anthropic-key",
+        "x-pass-x-goog-api-key": "attacker-google-key",
+        "x-pass-host": "evil.example.com",
+        "x-pass-content-length": "0",
+        "x-pass-x-amz-security-token": "attacker-aws-token",
+        # Legitimate x-pass- header that should still be forwarded
+        "x-pass-anthropic-beta": "context-1m-2025-08-07",
+        "content-type": "application/json",
+    }
+
+    result = BasePassthroughUtils.forward_headers_from_request(
+        request_headers=request_headers,
+        headers=proxy_headers.copy(),
+        forward_headers=False,
+    )
+
+    # Protected headers must retain the proxy-configured values
+    assert result["authorization"] == "Bearer proxy-upstream-key"
+    assert result["api-key"] == "proxy-azure-key"
+    assert result["x-api-key"] == "proxy-anthropic-key"
+    assert result["x-goog-api-key"] == "proxy-google-key"
+
+    # Protocol headers must not be injected
+    assert "host" not in result
+    assert "content-length" not in result
+
+    # AWS SigV4 headers must not be injected
+    assert "x-amz-security-token" not in result
+
+    # Legitimate non-protected x-pass- header still forwarded
+    assert result["anthropic-beta"] == "context-1m-2025-08-07"
+
+    # Header name must be normalized to lowercase in output
+    assert "Anthropic-Beta" not in result
+
+
 @pytest.mark.asyncio
 async def test_vertex_passthrough_custom_model_name_replaced_in_url():
     """