diff --git a/litellm/proxy/pass_through_endpoints/pass_through_endpoints.py b/litellm/proxy/pass_through_endpoints/pass_through_endpoints.py
index 356807415de..4d95fda0a44 100644
--- a/litellm/proxy/pass_through_endpoints/pass_through_endpoints.py
+++ b/litellm/proxy/pass_through_endpoints/pass_through_endpoints.py
@@ -2062,7 +2062,8 @@ class InitPassThroughEndpointHelpers:
         """
         ## CHECK IF MAPPED PASS THROUGH ENDPOINT
         for mapped_route in LiteLLMRoutes.mapped_pass_through_routes.value:
-            if route.startswith(mapped_route):
+            full_mapped_route = InitPassThroughEndpointHelpers._build_full_path_with_root(mapped_route)
+            if route.startswith(full_mapped_route):
                 return True
 
         # Fast path: check if any registered route key contains this path
diff --git a/tests/test_litellm/proxy/pass_through_endpoints/test_pass_through_endpoints.py b/tests/test_litellm/proxy/pass_through_endpoints/test_pass_through_endpoints.py
index 7ec97ddc185..71420c23ad1 100644
--- a/tests/test_litellm/proxy/pass_through_endpoints/test_pass_through_endpoints.py
+++ b/tests/test_litellm/proxy/pass_through_endpoints/test_pass_through_endpoints.py
@@ -2369,3 +2369,42 @@ def test_get_registered_pass_through_route_with_custom_root():
 
     # Clean up
     _registered_pass_through_routes.clear()
+
+
+def test_mapped_pass_through_routes_with_server_root_path():
+    """
+    Mapped passthrough routes (vertex_ai, bedrock, etc) should match
+    even when SERVER_ROOT_PATH is set and the incoming route is prefixed.
+
+    Regression test for https://github.com/BerriAI/litellm/issues/22272
+    """
+    from litellm.proxy.pass_through_endpoints.pass_through_endpoints import (
+        InitPassThroughEndpointHelpers,
+    )
+
+    with patch(
+        "litellm.proxy.pass_through_endpoints.pass_through_endpoints.get_server_root_path"
+    ) as mock_get_root:
+        mock_get_root.return_value = "/litellm"
+
+        # prefixed route should match mapped routes like /vertex_ai
+        assert (
+            InitPassThroughEndpointHelpers.is_registered_pass_through_route(
+                "/litellm/vertex_ai/v1/projects/foo"
+            )
+            is True
+        )
+        assert (
+            InitPassThroughEndpointHelpers.is_registered_pass_through_route(
+                "/litellm/bedrock/model/invoke"
+            )
+            is True
+        )
+
+        # bare route without prefix should not match when root is set
+        assert (
+            InitPassThroughEndpointHelpers.is_registered_pass_through_route(
+                "/vertex_ai/v1/projects/foo"
+            )
+            is False
+        )