diff --git a/litellm/main.py b/litellm/main.py
index 2d239e6840a..65a06b9d42a 100644
--- a/litellm/main.py
+++ b/litellm/main.py
@@ -119,6 +119,7 @@ from litellm.llms.bedrock.common_utils import (
     without_bedrock_route_prefix,
 )
 from litellm.llms.bedrock_mantle.chat.claude_transformation import bedrock_mantle_chat_config
+from litellm.llms.bedrock_mantle.common_utils import is_mantle_claude_model
 from litellm.llms.cohere.common_utils import CohereModelInfo
 from litellm.llms.custom_httpx.http_handler import AsyncHTTPHandler, HTTPHandler, http2_enabled
 from litellm.llms.openai.chat.gpt_5_transformation import OpenAIGPT5Config
@@ -1092,6 +1093,8 @@ def _is_claude_tool_target(custom_llm_provider: str | None, model: str) -> bool:
 
 
 def _is_claude_prompt_cache_target(custom_llm_provider: str | None, model: str, base_model: str | None) -> bool:
+    if custom_llm_provider == "bedrock_mantle":
+        return is_mantle_claude_model(model)
     if custom_llm_provider in ("anthropic", "bedrock") and "claude" not in model.lower():
         return base_model is not None and "claude" in base_model.lower()
     return _is_claude_tool_target(custom_llm_provider=custom_llm_provider, model=model)
diff --git a/tests/unit/test_main.py b/tests/unit/test_main.py
index c2d0506d52d..5cfb7b8e370 100644
--- a/tests/unit/test_main.py
+++ b/tests/unit/test_main.py
@@ -731,6 +731,34 @@ def test_breakpoints_on_one_converse_tool_result_take_one_slot_under_drop_params
     assert _converse_cache_points(json.loads(route.calls.last.request.content)) == ("system", *("message",) * 3)
 
 
+def test_a_breakpoint_reaches_bedrock_mantle_claude_as_cache_control(respx_mock: respx.MockRouter):
+    route: Final = respx_mock.post("https://bedrock-mantle.us-east-1.api.aws/anthropic/v1/messages").respond(
+        json={
+            "id": "msg_1",
+            "type": "message",
+            "role": "assistant",
+            "model": "anthropic.claude-opus-5-5",
+            "content": [{"type": "text", "text": "hi"}],
+            "stop_reason": "end_turn",
+            "usage": {"input_tokens": 1, "output_tokens": 1},
+        }
+    )
+
+    litellm.completion(
+        model="bedrock_mantle/anthropic.claude-opus-5-5",
+        messages=[
+            {"role": "system", "content": [{"type": "text", "text": "sys", "prompt_cache_breakpoint": _BREAKPOINT}]},
+            {"role": "user", "content": "Say hi."},
+        ],
+        api_key="fake",
+        aws_region_name="us-east-1",
+    )
+
+    assert json.loads(route.calls.last.request.content)["system"] == [
+        {"type": "text", "text": "sys", "cache_control": {"type": "ephemeral"}}
+    ]
+
+
 def test_completion_keeps_a_function_call_whose_id_only_looks_like_a_claude_server_tool(
     respx_mock: respx.MockRouter, openai_api_response
 ):