diff --git a/litellm/litellm_core_utils/litellm_logging.py b/litellm/litellm_core_utils/litellm_logging.py
index d8e70d3b125..79e67ef36f9 100644
--- a/litellm/litellm_core_utils/litellm_logging.py
+++ b/litellm/litellm_core_utils/litellm_logging.py
@@ -1135,25 +1135,41 @@ class Logging(LiteLLMLoggingBaseClass):
             dynamic_callback_params=self.standard_callback_dynamic_params,
         )
 
-        if custom_logger:
-            breakpoints_before: Final = AnthropicCacheControlHook.count_request_cache_breakpoints(messages)
-            (
-                model,
-                messages,
-                non_default_params,
-            ) = await custom_logger.async_get_chat_completion_prompt(
-                model=model,
-                messages=messages,
-                non_default_params=non_default_params or {},
-                prompt_id=prompt_id,
-                prompt_spec=prompt_spec,
-                prompt_variables=prompt_variables,
-                dynamic_callback_params=self.standard_callback_dynamic_params,
-                litellm_logging_obj=self,
-                tools=tools,
-                prompt_label=prompt_label,
-                prompt_version=prompt_version,
+        # The Anthropic cache-control hook and the vector store hook both claim the single
+        # prompt-management slot; a request that seeds cache_control_injection_points (e.g. via
+        # `enable_anthropic_prompt_caching`) would otherwise starve knowledge-base retrieval, so
+        # run the vector store hook first when both apply to the same request.
+        vector_store_logger: Final = (
+            self._get_vector_store_pre_call_hook()
+            if isinstance(custom_logger, AnthropicCacheControlHook)
+            and litellm.vector_store_registry is not None
+            and litellm.vector_store_registry.get_vector_store_ids_to_run(
+                non_default_params=non_default_params, tools=tools
             )
+            else None
+        )
+        prompt_loggers: Final = tuple(logger for logger in (vector_store_logger, custom_logger) if logger is not None)
+
+        if prompt_loggers:
+            breakpoints_before: Final = AnthropicCacheControlHook.count_request_cache_breakpoints(messages)
+            for prompt_logger in prompt_loggers:
+                (
+                    model,
+                    messages,
+                    non_default_params,
+                ) = await prompt_logger.async_get_chat_completion_prompt(
+                    model=model,
+                    messages=messages,
+                    non_default_params=non_default_params or {},
+                    prompt_id=prompt_id,
+                    prompt_spec=prompt_spec,
+                    prompt_variables=prompt_variables,
+                    dynamic_callback_params=self.standard_callback_dynamic_params,
+                    litellm_logging_obj=self,
+                    tools=tools,
+                    prompt_label=prompt_label,
+                    prompt_version=prompt_version,
+                )
             if request_kwargs is not None:
                 AnthropicCacheControlHook.record_gateway_injection(
                     request_kwargs,
@@ -1289,19 +1305,26 @@ class Logging(LiteLLMLoggingBaseClass):
         # Vector Store / Knowledge Base hooks
         #########################################################
         if litellm.vector_store_registry is not None:
-            vector_store_custom_logger: Final = _init_custom_logger_compatible_class(
-                logging_integration="vector_store_pre_call_hook",
-                internal_usage_cache=None,
-                llm_router=None,
-            )
-            self.model_call_details["prompt_integration"] = vector_store_custom_logger.__class__.__name__
-            # Add to global callbacks so post-call hooks are invoked
-            if vector_store_custom_logger and vector_store_custom_logger not in litellm.callbacks:
-                litellm.logging_callback_manager.add_litellm_callback(vector_store_custom_logger)
-            return vector_store_custom_logger
+            vector_store_custom_logger: Final = self._get_vector_store_pre_call_hook()
+            if vector_store_custom_logger is not None:
+                return vector_store_custom_logger
 
         return None
 
+    def _get_vector_store_pre_call_hook(self) -> CustomLogger | None:
+        vector_store_custom_logger: Final = _init_custom_logger_compatible_class(
+            logging_integration="vector_store_pre_call_hook",
+            internal_usage_cache=None,
+            llm_router=None,
+        )
+        if vector_store_custom_logger is None:
+            return None
+        self.model_call_details["prompt_integration"] = vector_store_custom_logger.__class__.__name__
+        # Add to global callbacks so post-call hooks are invoked
+        if vector_store_custom_logger not in litellm.callbacks:
+            litellm.logging_callback_manager.add_litellm_callback(vector_store_custom_logger)
+        return vector_store_custom_logger
+
     def get_custom_logger_for_anthropic_cache_control_hook(self, non_default_params: dict) -> CustomLogger | None:
         if non_default_params.get("cache_control_injection_points", None):
             custom_logger: Final = _init_custom_logger_compatible_class(
diff --git a/tests/unit/litellm_core_utils/test_litellm_logging.py b/tests/unit/litellm_core_utils/test_litellm_logging.py
index 4b25da2ff79..20ae22b2eac 100644
--- a/tests/unit/litellm_core_utils/test_litellm_logging.py
+++ b/tests/unit/litellm_core_utils/test_litellm_logging.py
@@ -7267,6 +7267,98 @@ def test_prompt_hooks_skip_prompt_managers_when_no_prompt_id(logging_obj, tmp_pa
             litellm.logging_callback_manager.remove_callback_from_list_by_object(litellm.callbacks, hook)
 
 
+@pytest.mark.asyncio
+async def test_prompt_hooks_compose_vector_search_with_anthropic_cache_control(logging_obj, monkeypatch):
+    """
+    Regression for https://github.com/BerriAI/litellm/issues/40908: with
+    `enable_anthropic_prompt_caching` on, `get_custom_logger_for_prompt_management` selects
+    AnthropicCacheControlHook over VectorStorePreCallHook (first-match-wins), so a model
+    configured with `vector_store_ids` never retrieved from its knowledge base and
+    `vector_store_ids` leaked into the provider request. Both hooks must now run.
+    """
+    from litellm.integrations.anthropic_cache_control_hook import AnthropicCacheControlHook
+    from litellm.integrations.vector_store_integrations.vector_store_pre_call_hook import (
+        VectorStorePreCallHook,
+    )
+    from litellm.litellm_core_utils import litellm_logging as logging_module
+    from litellm.types.vector_stores import (
+        LiteLLM_ManagedVectorStore,
+        VectorStoreResultContent,
+        VectorStoreSearchResponse,
+        VectorStoreSearchResult,
+    )
+    from litellm.vector_stores.vector_store_registry import VectorStoreRegistry
+
+    model = "bedrock/anthropic.claude-3-5-haiku-20241022-v1:0"
+    messages = [{"role": "user", "content": "What does the handbook say about refunds?"}]
+    params = {"custom_llm_provider": "bedrock", "vector_store_ids": ["vs_123"]}
+
+    monkeypatch.setattr(
+        litellm,
+        "vector_store_registry",
+        VectorStoreRegistry(
+            vector_stores=[LiteLLM_ManagedVectorStore(vector_store_id="vs_123", custom_llm_provider="bedrock")]
+        ),
+    )
+    monkeypatch.setattr(litellm, "enable_anthropic_prompt_caching", True)
+
+    AnthropicCacheControlHook.maybe_seed_default_injection_points(
+        non_default_params=params, messages=messages, model=model, custom_llm_provider="bedrock"
+    )
+    assert "cache_control_injection_points" in params
+
+    selected = logging_obj.get_custom_logger_for_prompt_management(
+        model=model, non_default_params=params, tools=None, prompt_id=None
+    )
+    assert isinstance(selected, AnthropicCacheControlHook)
+
+    class _RecordingRouter:
+        def __init__(self) -> None:
+            self.calls: list[dict[str, object]] = []
+
+        async def avector_store_search(self, **kwargs: object) -> VectorStoreSearchResponse:
+            self.calls.append(kwargs)
+            return VectorStoreSearchResponse(
+                object="vector_store.search_results.page",
+                search_query="What does the handbook say about refunds?",
+                data=[
+                    VectorStoreSearchResult(
+                        score=1.0,
+                        content=[VectorStoreResultContent(text="Refunds take seven days", type="text")],
+                    )
+                ],
+            )
+
+    router = _RecordingRouter()
+    runtime = MagicMock()
+    runtime.llm_router.return_value = router
+    runtime.prisma_client.return_value = None
+    vector_store_hook = VectorStorePreCallHook(proxy_runtime=runtime)
+    previous_loggers = tuple(logging_module._in_memory_loggers)
+    logging_module._in_memory_loggers.clear()
+    logging_module._in_memory_loggers.append(vector_store_hook)
+    try:
+        _, result_messages, remaining_params = await logging_obj.async_get_chat_completion_prompt(
+            model=model,
+            messages=messages,
+            non_default_params=params,
+            prompt_variables=None,
+        )
+
+        assert len(router.calls) == 1
+        assert result_messages[0]["content"] == "Context:\n\nRefunds take seven days\n\n"
+        assert result_messages[1]["content"] == "What does the handbook say about refunds?"
+        assert result_messages[1]["cache_control"] == {"type": "ephemeral"}
+        assert "vector_store_ids" not in remaining_params
+        assert "cache_control_injection_points" not in remaining_params
+    finally:
+        litellm.logging_callback_manager.remove_callback_from_list_by_object(
+            litellm.callbacks, vector_store_hook, require_self=False
+        )
+        logging_module._in_memory_loggers.clear()
+        logging_module._in_memory_loggers.extend(previous_loggers)
+
+
 def test_newrelic_dispatch_prefers_otel_v2_when_flag_on(monkeypatch):
     """With LITELLM_OTEL_V2 on and operator credentials present, the "newrelic"
     callback builds the OTel v2 logger (per-team credential routing); with the