diff --git a/litellm/llms/bedrock/chat/invoke_transformations/anthropic_claude3_transformation.py b/litellm/llms/bedrock/chat/invoke_transformations/anthropic_claude3_transformation.py
index e5698843e8f..328c3a0b977 100644
--- a/litellm/llms/bedrock/chat/invoke_transformations/anthropic_claude3_transformation.py
+++ b/litellm/llms/bedrock/chat/invoke_transformations/anthropic_claude3_transformation.py
@@ -108,6 +108,9 @@ class AmazonAnthropicClaudeConfig(AmazonInvokeConfig, AnthropicConfig):
         _anthropic_request.pop("stream", None)
         # Bedrock Invoke doesn't support output_format parameter
         _anthropic_request.pop("output_format", None)
+        # Bedrock Invoke doesn't support output_config parameter
+        # Fixes: https://github.com/BerriAI/litellm/issues/22797
+        _anthropic_request.pop("output_config", None)
         if "anthropic_version" not in _anthropic_request:
             _anthropic_request["anthropic_version"] = self.anthropic_version
 
diff --git a/litellm/llms/bedrock/messages/invoke_transformations/anthropic_claude3_transformation.py b/litellm/llms/bedrock/messages/invoke_transformations/anthropic_claude3_transformation.py
index 9fae5fd2a17..b11215e7f6b 100644
--- a/litellm/llms/bedrock/messages/invoke_transformations/anthropic_claude3_transformation.py
+++ b/litellm/llms/bedrock/messages/invoke_transformations/anthropic_claude3_transformation.py
@@ -419,6 +419,10 @@ class AmazonAnthropicClaudeMessagesConfig(
                 anthropic_messages_request=anthropic_messages_request,
             )
 
+        # 5b. Strip `output_config` — Bedrock Invoke doesn't support it
+        # Fixes: https://github.com/BerriAI/litellm/issues/22797
+        anthropic_messages_request.pop("output_config", None)
+
         # 5a. Remove `custom` field from tools (Bedrock doesn't support it)
         # Claude Code sends `custom: {defer_loading: true}` on tool definitions,
         # which causes Bedrock to reject the request with "Extra inputs are not permitted"
diff --git a/tests/test_litellm/llms/bedrock/chat/invoke_transformations/test_bedrock_chat_invoke_transformations_anthropic_claude3_transformation.py b/tests/test_litellm/llms/bedrock/chat/invoke_transformations/test_bedrock_chat_invoke_transformations_anthropic_claude3_transformation.py
index d2fb45643de..cb05531c2f8 100644
--- a/tests/test_litellm/llms/bedrock/chat/invoke_transformations/test_bedrock_chat_invoke_transformations_anthropic_claude3_transformation.py
+++ b/tests/test_litellm/llms/bedrock/chat/invoke_transformations/test_bedrock_chat_invoke_transformations_anthropic_claude3_transformation.py
@@ -386,6 +386,40 @@ def test_opus_4_5_model_detection():
 #         f"computer-use beta should be kept, got: {anthropic_beta}"
 
 
+def test_output_config_removed_from_bedrock_chat_invoke_request():
+    """
+    Test that output_config parameter is stripped from Bedrock Chat Invoke requests.
+
+    Bedrock Invoke API doesn't support the output_config parameter (Anthropic-only).
+    Ensures the chat/invoke path mirrors the messages/invoke path fix.
+
+    Fixes: https://github.com/BerriAI/litellm/issues/22797
+    """
+    config = AmazonAnthropicClaudeConfig()
+
+    messages = [{"role": "user", "content": "test"}]
+
+    # Inject output_config into optional_params (simulates Anthropic SDK forwarding it)
+    optional_params = {
+        "max_tokens": 100,
+        "output_config": {"effort": "high"},
+    }
+
+    result = config.transform_request(
+        model="anthropic.claude-sonnet-4-20250514-v1:0",
+        messages=messages,
+        optional_params=optional_params,
+        litellm_params={},
+        headers={},
+    )
+
+    assert "output_config" not in result, (
+        f"output_config should be stripped for Bedrock Chat Invoke, got keys: {list(result.keys())}"
+    )
+    # Verify normal params survive
+    assert result["max_tokens"] == 100
+
+
 def test_output_format_removed_from_bedrock_invoke_request():
     """
     Test that output_format parameter is removed from Bedrock Invoke requests.
diff --git a/tests/test_litellm/llms/bedrock/messages/invoke_transformations/test_anthropic_claude3_transformation.py b/tests/test_litellm/llms/bedrock/messages/invoke_transformations/test_anthropic_claude3_transformation.py
index e0b06ced172..f69f478278f 100644
--- a/tests/test_litellm/llms/bedrock/messages/invoke_transformations/test_anthropic_claude3_transformation.py
+++ b/tests/test_litellm/llms/bedrock/messages/invoke_transformations/test_anthropic_claude3_transformation.py
@@ -275,3 +275,70 @@ def test_remove_scope_from_cache_control():
     # Verify scope is removed from messages
     assert "scope" not in request["messages"][0]["content"][0]["cache_control"]
     assert request["messages"][0]["content"][0]["cache_control"]["type"] == "ephemeral"
+
+
+def test_bedrock_messages_strips_output_config():
+    """
+    Ensure output_config is stripped from the request before sending to
+    Bedrock Invoke, which doesn't support this Anthropic-specific parameter.
+
+    Regression test for: https://github.com/BerriAI/litellm/issues/22797
+    """
+    from litellm.types.router import GenericLiteLLMParams
+
+    cfg = AmazonAnthropicClaudeMessagesConfig()
+    messages = [{"role": "user", "content": [{"type": "text", "text": "Hello"}]}]
+    optional_params = {
+        "max_tokens": 4096,
+        "output_config": {
+            "effort": "high",
+        },
+    }
+
+    result = cfg.transform_anthropic_messages_request(
+        model="anthropic.claude-3-haiku-20240307-v1:0",
+        messages=messages,
+        anthropic_messages_optional_request_params=optional_params,
+        litellm_params=GenericLiteLLMParams(),
+        headers={},
+    )
+
+    assert "output_config" not in result, (
+        "output_config should be stripped — Bedrock Invoke rejects it"
+    )
+    # Other params should be preserved
+    assert result.get("max_tokens") == 4096
+
+
+def test_bedrock_messages_strips_output_config_with_output_format():
+    """
+    When both output_config and output_format are present, both should be
+    stripped (output_format is converted to inline schema, output_config
+    is simply dropped).
+    """
+    from litellm.types.router import GenericLiteLLMParams
+
+    cfg = AmazonAnthropicClaudeMessagesConfig()
+    messages = [{"role": "user", "content": [{"type": "text", "text": "Hello"}]}]
+    optional_params = {
+        "max_tokens": 4096,
+        "output_config": {"effort": "low"},
+        "output_format": {
+            "type": "json_schema",
+            "schema": {
+                "type": "object",
+                "properties": {"answer": {"type": "string"}},
+            },
+        },
+    }
+
+    result = cfg.transform_anthropic_messages_request(
+        model="anthropic.claude-3-haiku-20240307-v1:0",
+        messages=messages,
+        anthropic_messages_optional_request_params=optional_params,
+        litellm_params=GenericLiteLLMParams(),
+        headers={},
+    )
+
+    assert "output_config" not in result
+    assert "output_format" not in result