diff --git a/litellm/proxy/config_resolvers/settings_store.py b/litellm/proxy/config_resolvers/settings_store.py
index 3fe869ee2ce..b6e10937eab 100644
--- a/litellm/proxy/config_resolvers/settings_store.py
+++ b/litellm/proxy/config_resolvers/settings_store.py
@@ -33,6 +33,9 @@ class SettingsStore(MutableMapping[str, JsonValue]):
         self._yaml_values = MappingProxyType(dict(mapping))
         self._clear_runtime()
 
+    def config_value(self, key: str) -> JsonValue:
+        return self._yaml_values.get(key)
+
     def apply_db_row(self, row: DbRow, db_row: Mapping[str, JsonValue]) -> None:
         previous_row: Final = self._database_rows.get(row, _EMPTY_VALUES)
         self._database_rows = MappingProxyType({**self._database_rows, row: MappingProxyType(dict(db_row))})
diff --git a/litellm/proxy/proxy_server.py b/litellm/proxy/proxy_server.py
index 6a720a066b4..599e9353574 100644
--- a/litellm/proxy/proxy_server.py
+++ b/litellm/proxy/proxy_server.py
@@ -4858,9 +4858,16 @@ class ProxyConfig:
         )
 
     def _load_yaml_settings_stores(self, config: Mapping[str, object]) -> None:
+        global config_passthrough_endpoints
         for section, store in self._settings_stores.items():
             store.load_yaml(_as_settings_mapping(config.get(section)))
             store.apply_db_row(section, _EMPTY_SETTINGS_MAPPING)
+        yaml_endpoints: Final = self.settings.config_value("pass_through_endpoints")
+        config_passthrough_endpoints = (
+            [dict(endpoint) for endpoint in yaml_endpoints if isinstance(endpoint, dict)]
+            if isinstance(yaml_endpoints, list)
+            else None
+        )
 
     def _config_with_resolved_settings(self, config: Mapping[str, object]) -> dict[str, object]:
         return {  # mutable-ok: get_config preserves the mutable mapping contract used by existing loaders
@@ -6161,7 +6168,6 @@ class ProxyConfig:
 
             ## pass through endpoints
             if general_settings.get("pass_through_endpoints", None) is not None:
-                config_passthrough_endpoints = general_settings["pass_through_endpoints"]
                 await initialize_pass_through_endpoints(
                     pass_through_endpoints=general_settings["pass_through_endpoints"],
                     config_file_path=config_file_path,
@@ -7265,17 +7271,7 @@ class ProxyConfig:
         db_values: Mapping[str, SettingsJsonValue],
         previous_retention_values: tuple[SettingsJsonValue | None, ...],
     ) -> None:
-        if (
-            any(
-                key in db_values
-                for key in (
-                    "maximum_spend_logs_retention_period",
-                    "maximum_autorouter_session_retention_period",
-                    "maximum_health_check_retention_period",
-                )
-            )
-            and previous_retention_values != self._resolved_retention_values()
-        ):
+        if previous_retention_values != self._resolved_retention_values():
             await self._reschedule_spend_log_cleanup_job()
 
     async def _apply_ssrf_settings(self, db_values: Mapping[str, SettingsJsonValue]) -> None:
diff --git a/tests/test_litellm/proxy/proxy_server/test_proxy_config.py b/tests/test_litellm/proxy/proxy_server/test_proxy_config.py
index 245ce0b4b21..c8d1f9b2f05 100644
--- a/tests/test_litellm/proxy/proxy_server/test_proxy_config.py
+++ b/tests/test_litellm/proxy/proxy_server/test_proxy_config.py
@@ -3775,6 +3775,23 @@ async def test_ProxyConfig__update_general_settings_skips_redundant_retention_re
     reschedule.assert_not_awaited()
 
 
+@pytest.mark.asyncio
+async def test_ProxyConfig__update_general_settings_reschedules_after_retention_key_deletion(monkeypatch):
+    from litellm.proxy import proxy_server
+
+    pc = ProxyConfig()
+    reschedule: Final = AsyncMock()
+    monkeypatch.setattr(proxy_server, "general_settings", {})
+    monkeypatch.setattr(pc, "_reschedule_spend_log_cleanup_job", reschedule)
+
+    await pc._update_general_settings({"maximum_health_check_retention_period": "30d"})
+    reschedule.reset_mock()
+
+    await pc._update_general_settings({})
+
+    reschedule.assert_awaited_once()
+
+
 @pytest.mark.asyncio
 async def test_ProxyConfig__update_general_settings_dispatches_every_side_effect_handler(monkeypatch):
     pc = ProxyConfig()
@@ -3870,6 +3887,19 @@ async def test_ProxyConfig__update_config_from_db_resolves_through_settings_stor
     assert pc.settings.source("max_parallel_requests") == "db"
 
 
+def test_ProxyConfig_load_yaml_settings_stores_keeps_db_endpoints_out_of_config_baseline():
+    from litellm.proxy import proxy_server
+
+    pc = ProxyConfig()
+    config_endpoint: Final = {"path": "/config", "target": "https://config.example"}
+    db_endpoint: Final = {"id": "db-endpoint", "path": "/db", "target": "https://db.example"}
+
+    pc._load_yaml_settings_stores({"general_settings": {"pass_through_endpoints": [config_endpoint]}})
+    pc.settings.apply_db_row("general_settings", {"pass_through_endpoints": [db_endpoint]})
+
+    assert proxy_server.config_passthrough_endpoints == [config_endpoint]
+
+
 @pytest.mark.asyncio
 async def test_ProxyConfig_add_deployment_continues_after_null_pass_through_endpoints(monkeypatch):
     from litellm.proxy import proxy_server