diff --git a/gitnexus/src/config/ignore-service.ts b/gitnexus/src/config/ignore-service.ts
index 02a26068e..66516d7d4 100644
--- a/gitnexus/src/config/ignore-service.ts
+++ b/gitnexus/src/config/ignore-service.ts
@@ -3,6 +3,7 @@ import fs from 'fs/promises';
 import nodePath from 'path';
 import type { Path } from 'path-scurry';
 import { logger } from '../core/logger.js';
+import { getGlobalDir } from '../storage/repo-manager.js';
 
 const DEFAULT_IGNORE_LIST = new Set([
   // Version Control
@@ -350,8 +351,18 @@ export const isHardcodedIgnoredDirectory = (name: string): boolean => {
 export interface IgnoreOptions {
   /** Skip .gitignore parsing, only read .gitnexusignore. Defaults to GITNEXUS_NO_GITIGNORE env var. */
   noGitignore?: boolean;
+  /** Skip the user-level global ignore file. Defaults to GITNEXUS_NO_GLOBAL_IGNORE env var. */
+  noGlobalIgnore?: boolean;
 }
 
+/**
+ * Path to the user-level global ignore file, applied across every indexed
+ * repo (#2606). Same `.gitnexusignore` syntax; lives alongside
+ * `registry.json`/`config.json` under the existing global GitNexus
+ * directory (`GITNEXUS_HOME` or `~/.gitnexus`) rather than a new location.
+ */
+export const getGlobalIgnorePath = (): string => nodePath.join(getGlobalDir(), 'ignore');
+
 export const loadIgnoreRules = async (
   repoPath: string,
   options?: IgnoreOptions,
@@ -359,6 +370,23 @@ export const loadIgnoreRules = async (
   const ig = ignore();
   let hasRules = false;
 
+  // Global ignore file is added first so per-repo .gitignore/.gitnexusignore
+  // rules layer on top and can negate it, mirroring the existing
+  // .gitignore -> .gitnexusignore precedence below (#2606).
+  const skipGlobalIgnore = options?.noGlobalIgnore ?? !!process.env.GITNEXUS_NO_GLOBAL_IGNORE;
+  if (!skipGlobalIgnore) {
+    try {
+      const content = await fs.readFile(getGlobalIgnorePath(), 'utf-8');
+      ig.add(content);
+      hasRules = true;
+    } catch (err: unknown) {
+      const code = (err as NodeJS.ErrnoException).code;
+      if (code !== 'ENOENT') {
+        logger.warn(`  Warning: could not read global ignore file: ${(err as Error).message}`);
+      }
+    }
+  }
+
   // Allow users to bypass .gitignore parsing (e.g. when .gitignore accidentally excludes source files)
   const skipGitignore = options?.noGitignore ?? !!process.env.GITNEXUS_NO_GITIGNORE;
   const filenames = skipGitignore ? ['.gitnexusignore'] : ['.gitignore', '.gitnexusignore'];
diff --git a/gitnexus/test/unit/ignore-service.test.ts b/gitnexus/test/unit/ignore-service.test.ts
index 9f989bbcc..639c9d78f 100644
--- a/gitnexus/test/unit/ignore-service.test.ts
+++ b/gitnexus/test/unit/ignore-service.test.ts
@@ -7,6 +7,7 @@ import {
   isHardcodedIgnoredDirectory,
   loadIgnoreRules,
   createIgnoreFilter,
+  getGlobalIgnorePath,
 } from '../../src/config/ignore-service.js';
 import { _captureLogger } from '../../src/core/logger.js';
 
@@ -658,3 +659,116 @@ describe('loadIgnoreRules — GITNEXUS_NO_GITIGNORE env var', () => {
     }
   });
 });
+
+// ─── User-level global ignore file (#2606) ───────────────────────────
+//
+// IgnoreService previously read only per-repo .gitignore/.gitnexusignore.
+// #2606 asked for a global layer so an exclusion meant to apply to every
+// indexed repo is declared once, under the existing GITNEXUS_HOME/~/.gitnexus
+// global directory (same one that already holds registry.json/config.json),
+// rather than being repeated per repo or hand-patched into node_modules.
+//
+// Precedence: the global file is added to the `ignore` instance BEFORE
+// .gitignore/.gitnexusignore, so per-repo rules can negate it — the same
+// last-add-wins mechanism the #771 tests above already lock in one layer up.
+describe('loadIgnoreRules — user-level global ignore file (#2606)', () => {
+  let repoDir: string;
+  let globalHomeDir: string;
+  let originalGitnexusHome: string | undefined;
+  let originalNoGlobalIgnore: string | undefined;
+
+  beforeEach(async () => {
+    repoDir = await fs.mkdtemp(path.join(os.tmpdir(), 'gn-global-ignore-repo-'));
+    globalHomeDir = await fs.mkdtemp(path.join(os.tmpdir(), 'gn-global-ignore-home-'));
+    originalGitnexusHome = process.env.GITNEXUS_HOME;
+    originalNoGlobalIgnore = process.env.GITNEXUS_NO_GLOBAL_IGNORE;
+    process.env.GITNEXUS_HOME = globalHomeDir;
+  });
+
+  afterEach(async () => {
+    if (originalGitnexusHome === undefined) {
+      delete process.env.GITNEXUS_HOME;
+    } else {
+      process.env.GITNEXUS_HOME = originalGitnexusHome;
+    }
+    if (originalNoGlobalIgnore === undefined) {
+      delete process.env.GITNEXUS_NO_GLOBAL_IGNORE;
+    } else {
+      process.env.GITNEXUS_NO_GLOBAL_IGNORE = originalNoGlobalIgnore;
+    }
+    await fs.rm(repoDir, { recursive: true, force: true });
+    await fs.rm(globalHomeDir, { recursive: true, force: true });
+  });
+
+  it('getGlobalIgnorePath resolves under GITNEXUS_HOME', () => {
+    expect(getGlobalIgnorePath()).toBe(path.join(globalHomeDir, 'ignore'));
+  });
+
+  it('honours rules from the global ignore file when no per-repo files exist', async () => {
+    await fs.writeFile(getGlobalIgnorePath(), 'docs/\n');
+    const ig = await loadIgnoreRules(repoDir);
+    expect(ig).not.toBeNull();
+    expect(ig!.ignores('docs/guide.md')).toBe(true);
+    expect(ig!.ignores('src/index.ts')).toBe(false);
+  });
+
+  it('per-repo .gitnexusignore can negate a global-ignore rule', async () => {
+    await fs.writeFile(getGlobalIgnorePath(), 'docs/\n');
+    await fs.writeFile(path.join(repoDir, '.gitnexusignore'), '!docs/\n');
+    const ig = await loadIgnoreRules(repoDir);
+    expect(ig).not.toBeNull();
+    expect(ig!.ignores('docs/guide.md')).toBe(false);
+  });
+
+  it('GITNEXUS_NO_GLOBAL_IGNORE skips the global file entirely', async () => {
+    await fs.writeFile(getGlobalIgnorePath(), 'docs/\n');
+    process.env.GITNEXUS_NO_GLOBAL_IGNORE = '1';
+    const ig = await loadIgnoreRules(repoDir);
+    expect(ig).toBeNull();
+  });
+
+  it('noGlobalIgnore option skips the global file entirely', async () => {
+    await fs.writeFile(getGlobalIgnorePath(), 'docs/\n');
+    const ig = await loadIgnoreRules(repoDir, { noGlobalIgnore: true });
+    expect(ig).toBeNull();
+  });
+
+  it('missing global ignore file is a no-op (byte-identical to pre-#2606 behaviour)', async () => {
+    // globalHomeDir exists but has no `ignore` file in it, and no per-repo files either.
+    const ig = await loadIgnoreRules(repoDir);
+    expect(ig).toBeNull();
+  });
+
+  it('still combines global, .gitignore, and .gitnexusignore rules together', async () => {
+    await fs.writeFile(getGlobalIgnorePath(), 'docs/\n');
+    await fs.writeFile(path.join(repoDir, '.gitignore'), 'data/\n');
+    await fs.writeFile(path.join(repoDir, '.gitnexusignore'), 'vendor/\n');
+    const ig = await loadIgnoreRules(repoDir);
+    expect(ig).not.toBeNull();
+    expect(ig!.ignores('docs/guide.md')).toBe(true);
+    expect(ig!.ignores('data/file.txt')).toBe(true);
+    expect(ig!.ignores('vendor/lib.js')).toBe(true);
+    expect(ig!.ignores('src/index.ts')).toBe(false);
+  });
+
+  // Root bypasses POSIX read-permission checks (see the analogous EACCES
+  // test above for .gitignore), so this can't reproduce under uid=0.
+  it.skipIf(process.platform === 'win32' || process.getuid?.() === 0)(
+    'warns on an unreadable global ignore file but does not throw',
+    async () => {
+      const globalIgnorePath = getGlobalIgnorePath();
+      await fs.writeFile(globalIgnorePath, 'docs/\n');
+      await fs.chmod(globalIgnorePath, 0o000);
+
+      const cap = _captureLogger();
+      const ig = await loadIgnoreRules(repoDir);
+      expect(ig).toBeNull();
+      expect(
+        cap.records().some((r) => String(r.msg ?? '').includes('global ignore file')),
+      ).toBe(true);
+
+      cap.restore();
+      await fs.chmod(globalIgnorePath, 0o644);
+    },
+  );
+});